cis-Acting RNA elements in the hepatitis C virus RNA genome
نویسندگان
چکیده
منابع مشابه
Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.
Alphavirus genome replication is a multistep asymmetric process. Several lines of evidence suggest that the template preference of the RNA replicase is regulated by proteolytic cleavage of the viral nonstructural polyprotein. Cis-acting RNA elements in the viral genome also play crucial roles in regulating genome replication and subgenomic RNA transcription. In this report, a series of RNA temp...
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Bamboo mosaic virus (BaMV), which belongs to the genus Potexvirus in the family Alphaflexiviridae, has a single-stranded positive-sense RNA genome that is approximately 6400 nucleotides (nts) in length. Positive-sense RNA viruses can use genomic RNA as a template for translation and replication after entering a suitable host cell. Furthermore, such viral RNA is recognized by capsid protein for ...
متن کاملcis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome.
The cis-replicating RNA elements in the 5' and 3' nontranslated regions (NTRs) of the hepatitis C virus (HCV) genome have been thoroughly studied before. However, no cis-replicating elements have been identified in the coding sequences of the HCV polyprotein until very recently. The existence of highly conserved and stable stem-loop structures in the RNA polymerase NS5B coding sequence, however...
متن کاملCis–Acting RNA Elements of Human Immunodeficiency Virus
The World Health Organization has indicated that effective control of the HIV/AIDS pandemic is the world’s most urgent public health challenge. The 2009 UNAIDS Global Facts and Figures report estimated that almost 60 million people have been infected with the virus and that 25 million AIDS-related deaths have occurred since the pandemic began in the early 1980s. In 2008, there were approximatel...
متن کاملQ beta RNA bacteriophage: mapping cis-acting elements within an RNA genome.
We have identified, for the first time, regions of cis-acting RNA elements within the bacteriophage Q beta replicase cistron by analyzing the infectivities of 76 replicase gene mutant phages in the presence of a helper replicase. Two separate classes of mutant Q beta phage genomes (35 different insertion mutants, each containing an insertion of 3 to 15 nucleotides within the replicase gene, and...
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ژورنال
عنوان ژورنال: Virus Research
سال: 2015
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2014.12.029